Endothelial pathophysiology, glycosaminoglycans and glycocalyx
نویسندگان
چکیده
منابع مشابه
The Structural Stability of the Endothelial Glycocalyx after Enzymatic Removal of Glycosaminoglycans
RATIONALE It is widely believed that glycosaminoglycans (GAGs) and bound plasma proteins form an interconnected gel-like structure on the surface of endothelial cells (the endothelial glycocalyx layer-EGL) that is stabilized by the interaction of its components. However, the structural organization of GAGs and proteins and the contribution of individual components to the stability of the EGL ar...
متن کاملEndothelial Glycocalyx and Cardiopulmonary Bypass.
On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocaly...
متن کاملThe endothelial glycocalyx
Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...
متن کاملThe Endothelial Glycocalyx: Visualization and Measurement
The endothelial glycocalyx is a hair-like surface layer mainly consisted of glycosaminoglycans (GAGs) that includes heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA) and its bearing core proteins (syndecan, glypican, and perlecan). This mini review presents the visualization and measurement techniques of the endothelial glycocalyx up to now, providing insight to the diagn...
متن کاملMechanotransduction and flow across the endothelial glycocalyx.
In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspec...
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ژورنال
عنوان ژورنال: Clinical Management Issues
سال: 2015
ISSN: 2283-3137,1973-4832
DOI: 10.7175/cmi.v4i4s.1087